A SIMPLE KEY FOR PKRRATING UNVEILED

The activated enzyme then phosphorylates its major substrate, the translational initiation factor eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs into a conserved spouse and children of 4 protein kinases (PKR, PERK, GCN2, HRI) that every one phosphorylate eIF2α in reaction to different stimuli12, triggering the built